Gene Card 基因详情

支持统一新 ID、NCBI Gene ID、GeneID、locus_tag、Transcript ID、Protein ID，以及已人工核对的文献基因名查询。页面会先解析到丹参统一基因，再整合坐标、序列、注释、亚细胞定位、EMS 突变和下载入口。

当前解析结果

`SmilChr06G002336`

染色体: Chr06 坐标: 33900763-33916362 链方向: + 类型: protein_coding

基本信息

统一新 Gene ID	`SmilChr06G002336`
名称	SmilChr06G002336
描述	DNA topoisomerase 3-alpha
染色体 / SeqID	Chr06 / NC_080392.1
坐标与链方向	33900763 - 33916362 / `+`

ID 对照

NCBI Gene ID	`LOC130989160`
GeneID	`130989160`
locus_tag	`-`
NCBI Name	`LOC130989160`
原始查询	`LOC130989160`

查看完整 ID 对照表

功能注释

来源	GFF basic annotation; NCBI GO GAF; KEGG smil; Pfam-A/HMMER; Arabidopsis/Rice homolog
描述	DNA topoisomerase 3-alpha
产物	DNA topoisomerase 3-alpha
Arabidopsis	`AT5G63920` (TOP3A) topoisomerase 3alpha [Source:NCBI gene (formerly Entrezgene);Acc:836513] identity=69.1; qcov=1.01; evalue=0; confidence=high
Rice	`Os03g0165000` (TOP3) - identity=66.6; qcov=1.02; evalue=0; confidence=high
GO	GO:0003677 (DNA binding); GO:0003917 (DNA topoisomerase type I (single strand cut, ATP-independent) activity); GO:0005634 (nucleus); GO:0005694 (chromosome); GO:0006265 (DNA topological change); GO:0008270 (zinc ion binding)
KEGG	smil03440 (Homologous recombination - Salvia miltiorrhiza (redroot sage)); smil03460 (Fanconi anemia pathway - Salvia miltiorrhiza (redroot sage))
Pfam	PF01131 (Topoisom_bac); PF01396 (Zn_ribbon_Top1); PF01751 (Toprim); PF06839 (Zn_ribbon_GRF)
InterPro	-
eggNOG	-
NR	GeneID:130989160

打开注释模块

亚细胞定位 Top 5

Rank	定位位置	中文	Score	Protein ID
1	Nucleus	细胞核	1.00000	`XP_057769082.1`
2	Cytoplasm	细胞质	1.00000	`XP_057769082.1`
3	Cytosol	细胞质基质	0.80000	`XP_057769082.1`
4	Nucleoplasm	核质	0.60000	`XP_057769083.1`
5	Nuclear body	核内小体	0.20000	`XP_057769082.1`

进入亚细胞定位查询

EMS 诱变突变

下表显示该基因在丹参 EMS 材料中的前 12 个候选突变；完整结果可进入 EMS 突变库继续筛选或下载。

位置	REF	ALT	类型	影响	携带材料数	材料
`Chr6:33900851`	`C`	`T`	EMS_canonical_SNV	CDS_variant	3	B114,B27,B57
`Chr6:33900943`	`GT`	`G`	1bp_deletion	frameshift_variant	1	C42
`Chr6:33900943`	`GT`	`G`	1bp_deletion	CDS_variant	1	C42
`Chr6:33902065`	`C`	`T`	EMS_canonical_SNV	CDS_variant	2	B23,D3
`Chr6:33902849`	`C`	`T`	EMS_canonical_SNV	CDS_variant	2	B61,C47
`Chr6:33903032`	`C`	`T`	EMS_canonical_SNV	CDS_variant	1	B33
`Chr6:33903996`	`TC`	`T`	1bp_deletion	frameshift_variant	1	C7
`Chr6:33903996`	`TC`	`T`	1bp_deletion	CDS_variant	1	C7
`Chr6:33904787`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	B80
`Chr6:33910101`	`G`	`A`	EMS_canonical_SNV	CDS_variant	3	B114,B27,B57
`Chr6:33910186`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	B77
`Chr6:33911292`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	D10

进入 EMS 突变库

预测功能结构域

结构域结果来自 Pfam-A HMM 数据库和 HMMER hmmscan；位置为对应蛋白序列上的氨基酸坐标。

XP_057769082.1

919 aa

460

919

Toprim

Topoisom_bac

Zn_ribbon_Top1

Zn_ribbon_GRF

PF01751 Toprim 14-160 aa PF01131 Topoisom_bac 177-596 aa PF01396 Zn_ribbon_Top1 643-681 aa PF06839 Zn_ribbon_GRF 809-848 aa

XP_057769083.1

915 aa

458

915

Toprim

Topoisom_bac

Zn_ribbon_Top1

Zn_ribbon_GRF

PF01751 Toprim 14-160 aa PF01131 Topoisom_bac 177-596 aa PF01396 Zn_ribbon_Top1 643-681 aa PF06839 Zn_ribbon_GRF 805-844 aa

Protein ID	来源	结构域编号	结构域名称	类型	起始 aa	终止 aa	E-value	Score	说明
`XP_057769082.1`	Pfam	`PF01751`	Toprim	Family	14	160	6e-12	46.3	Toprim domain
`XP_057769082.1`	Pfam	`PF01131`	Topoisom_bac	Family	177	596	1.2e-108	364.4	DNA topoisomerase
`XP_057769082.1`	Pfam	`PF01396`	Zn_ribbon_Top1	Domain	643	681	3.7e-08	33.7	Topoisomerase DNA binding C4 zinc finger
`XP_057769082.1`	Pfam	`PF06839`	Zn_ribbon_GRF	Domain	809	848	1.8e-10	41.5	GRF zinc finger
`XP_057769083.1`	Pfam	`PF01751`	Toprim	Family	14	160	6e-12	46.3	Toprim domain
`XP_057769083.1`	Pfam	`PF01131`	Topoisom_bac	Family	177	596	1.2e-108	364.4	DNA topoisomerase
`XP_057769083.1`	Pfam	`PF01396`	Zn_ribbon_Top1	Domain	643	681	3.7e-08	33.7	Topoisomerase DNA binding C4 zinc finger
`XP_057769083.1`	Pfam	`PF06839`	Zn_ribbon_GRF	Domain	805	844	1.8e-10	41.5	GRF zinc finger

cDNA / CDS / Protein 序列

下载基因组 DNA（仅基因区域）

每个公开基因均提供参考注释对应的转录本序列；蛋白编码基因另提供 CDS 和蛋白序列。非编码 RNA 不适用 CDS 或蛋白下载。真实 accession 的版本后缀予以保留。

cDNA

2 records

下载 cDNA FASTA

XM_057913099.1
CCATTTGAGTGTAAAAAACAAAACTCTCAGAAACCGGCAATTAGAACAATTGAGCATTTTCCGATGGCAGGCGGCGGAGGCGGGCGGTCAATAAGGGCGCTGAACGTGGCGGAGAAGCCTTCGGTGGCTAAGCAGGTGGCAGGTATACTCTCGAAGAATCCTTCGAGCGGCGGACTAAGAGTAAGAGACGGCCGGTCCAGATACAATAGGATATTCGAATTCAACTGCGTGGTTAGGAACCAGCAAATTCAAATGTCCTT...

XM_057913100.1
CCATTTGAGTGTAAAAAACAAAACTCTCAGAAACCGGCAATTAGAACAATTGAGCATTTTCCGATGGCAGGCGGCGGAGGCGGGCGGTCAATAAGGGCGCTGAACGTGGCGGAGAAGCCTTCGGTGGCTAAGCAGGTGGCAGGTATACTCTCGAAGAATCCTTCGAGCGGCGGACTAAGAGTAAGAGACGGCCGGTCCAGATACAATAGGATATTCGAATTCAACTGCGTGGTTAGGAACCAGCAAATTCAAATGTCCTT...

CDS

2 records

下载 CDS FASTA

LOC130989160
ATGGCAGGCGGCGGAGGCGGGCGGTCAATAAGGGCGCTGAACGTGGCGGAGAAGCCTTCGGTGGCTAAGCAGGTGGCAGGTATACTCTCGAAGAATCCTTCGAGCGGCGGACTAAGAGTAAGAGACGGCCGGTCCAGATACAATAGGATATTCGAATTCAACTGCGTGGTTAGGAACCAGCAAATTCAAATGTCCTTCACCTCCGTCACAGGCCACCTCATGGAGCTCGATTTTGACGATAGGTATCGCAAGTGGCACTC...

Protein

2 records

下载 Protein FASTA

XP_057769082.1
MAGGGGGRSIRALNVAEKPSVAKQVAGILSKNPSSGGLRVRDGRSRYNRIFEFNCVVRNQQIQMSFTSVTGHLMELDFDDRYRKWHSCDPADLYHAPVRKYVPQDKLDIQKTLEEEARKCQWLILWLDCDREGENIAFEVVDICMRANRNLNIWRARFSALTDRDIYDAITRLSPPNQLQAEAVDLRQEIDLRIGASFTRFQTMLLKDAFILDSTTDETNVVLSYGPCQFPTLGFVVERFWEIQSHQAEEFWTINCTHNS...

XP_057769083.1
MAGGGGGRSIRALNVAEKPSVAKQVAGILSKNPSSGGLRVRDGRSRYNRIFEFNCVVRNQQIQMSFTSVTGHLMELDFDDRYRKWHSCDPADLYHAPVRKYVPQDKLDIQKTLEEEARKCQWLILWLDCDREGENIAFEVVDICMRANRNLNIWRARFSALTDRDIYDAITRLSPPNQLQAEAVDLRQEIDLRIGASFTRFQTMLLKDAFILDSTTDETNVVLSYGPCQFPTLGFVVERFWEIQSHQAEEFWTINCTHNS...

上下游序列下载

upstream/downstream 最大各 10000 bp。负链基因会自动反向互补，使最终 FASTA 为转录方向 5′→3′。

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