Gene Card 基因详情

支持统一新 ID、NCBI Gene ID、GeneID、locus_tag、Transcript ID、Protein ID，以及已人工核对的文献基因名查询。页面会先解析到丹参统一基因，再整合坐标、序列、注释、亚细胞定位、EMS 突变和下载入口。

当前解析结果

`SmilChr06G002444`

染色体: Chr06 坐标: 35165770-35179223 链方向: + 类型: protein_coding

基本信息

统一新 Gene ID	`SmilChr06G002444`
名称	SmilChr06G002444
描述	serine/threonine-protein kinase ATR
染色体 / SeqID	Chr06 / NC_080392.1
坐标与链方向	35165770 - 35179223 / `+`

ID 对照

NCBI Gene ID	`LOC130989247`
GeneID	`130989247`
locus_tag	`-`
NCBI Name	`LOC130989247`
原始查询	`LOC130989247`

查看完整 ID 对照表

功能注释

来源	GFF basic annotation; NCBI GO GAF; KEGG smil; Pfam-A/HMMER; Arabidopsis/Rice homolog
描述	serine/threonine-protein kinase ATR
产物	serine/threonine-protein kinase ATR
Arabidopsis	`AT5G40820` (ATR) Ataxia telangiectasia-mutated and RAD3-like protein [Source:NCBI gene (formerly Entrezgene);Acc:834082] identity=61.3; qcov=1; evalue=0; confidence=high
Rice	`Os06g0724700` - identity=78.7; qcov=0.194; evalue=0; confidence=weak
GO	GO:0000077 (DNA damage checkpoint signaling); GO:0000723 (telomere maintenance); GO:0004674 (protein serine/threonine kinase activity); GO:0005515 (protein binding); GO:0005634 (nucleus); GO:0006468 (protein phosphorylation)
KEGG	smil03460 (Fanconi anemia pathway - Salvia miltiorrhiza (redroot sage))
Pfam	PF00454 (PI3_PI4_kinase); PF02259 (FAT); PF02260 (FATC); PF08064 (UME); PF23593 (HEAT_ATR); PF25030 (M-HEAT_ATR)
InterPro	-
eggNOG	-
NR	GeneID:130989247

打开注释模块

亚细胞定位 Top 5

Rank	定位位置	中文	Score	Protein ID
1	Nucleus	细胞核	1.00000	`XP_057769184.1`
2	Cytosol	细胞质基质	0.40000	`XP_057769187.1`
3	Cytoplasm	细胞质	0.20000	`XP_057769184.1`
4	Chromosome	染色体	0.00000	`XP_057769184.1`
5	Centromere	着丝粒	0.00000	`XP_057769184.1`

进入亚细胞定位查询

EMS 诱变突变

下表显示该基因在丹参 EMS 材料中的前 12 个候选突变；完整结果可进入 EMS 突变库继续筛选或下载。

位置	REF	ALT	类型	影响	携带材料数	材料
`Chr6:35167212`	`T`	`TAC`	2bp_insertion	frameshift_variant	8	B112,B125,B129,B139,B24,B38,B86,C33
`Chr6:35167216`	`C`	`CAA`	2bp_insertion	frameshift_variant	6	B125,B129,B139,B24,B38,C33
`Chr6:35167239`	`T`	`TTG`	2bp_insertion	stop_gained,frameshift_variant	5	B125,B139,B24,B38,C33
`Chr6:35167239`	`T`	`TTG`	2bp_insertion	CDS_variant	5	B125,B139,B24,B38,C33
`Chr6:35167260`	`G`	`A`	EMS_canonical_SNV	CDS_variant	3	B125,B38,C33
`Chr6:35168276`	`G`	`A`	EMS_canonical_SNV	CDS_variant	3	B13,C45,C52
`Chr6:35168567`	`G`	`A`	EMS_canonical_SNV	CDS_variant	3	B57,B90,B92
`Chr6:35169131`	`C`	`T`	EMS_canonical_SNV	CDS_variant	4	C17,C27,C63,D3
`Chr6:35169903`	`G`	`A`	EMS_canonical_SNV	CDS_variant	2	A18,B62
`Chr6:35170219`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	C23
`Chr6:35170287`	`TA`	`T`	1bp_deletion	frameshift_variant	26	A1,A18,A2,B109,B118,B122,B133,B136,B35,B56,B62,B63,B68,B73,B83,B85,B94,B99,C22,C30,C33,C37,C40,C74,C75,C85
`Chr6:35170291`	`A`	`AT`	1bp_insertion	frameshift_variant	26	A1,A18,A2,B109,B118,B122,B133,B136,B35,B56,B62,B63,B68,B73,B83,B85,B94,B99,C22,C30,C33,C37,C40,C74,C75,C85

进入 EMS 突变库

预测功能结构域

结构域结果来自 Pfam-A HMM 数据库和 HMMER hmmscan；位置为对应蛋白序列上的氨基酸坐标。

XP_057769184.1

2721 aa

1360

2721

UME

M-HEAT_ATR

FAT

HEAT_ATR

PI3_PI4_kinase

FATC

PF08064 UME 1103-1203 aa PF25030 M-HEAT_ATR 1486-1734 aa PF02259 FAT 1800-2178 aa PF23593 HEAT_ATR 2204-2302 aa PF00454 PI3_PI4_kinase 2405-2650 aa PF02260 FATC 2690-2721 aa

XP_057769185.1

2721 aa

1360

2721

UME

M-HEAT_ATR

FAT

HEAT_ATR

PI3_PI4_kinase

FATC

PF08064 UME 1103-1203 aa PF25030 M-HEAT_ATR 1486-1734 aa PF02259 FAT 1800-2178 aa PF23593 HEAT_ATR 2204-2302 aa PF00454 PI3_PI4_kinase 2405-2650 aa PF02260 FATC 2690-2721 aa

XP_057769186.1

2720 aa

1360

2720

UME

M-HEAT_ATR

FAT

HEAT_ATR

PI3_PI4_kinase

FATC

PF08064 UME 1102-1202 aa PF25030 M-HEAT_ATR 1485-1733 aa PF02259 FAT 1799-2177 aa PF23593 HEAT_ATR 2203-2301 aa PF00454 PI3_PI4_kinase 2404-2649 aa PF02260 FATC 2689-2720 aa

XP_057769187.1

2474 aa

1237

2474

UME

M-HEAT_ATR

FAT

HEAT_ATR

PI3_PI4_kinase

FATC

PF08064 UME 856-956 aa PF25030 M-HEAT_ATR 1239-1487 aa PF02259 FAT 1553-1931 aa PF23593 HEAT_ATR 1957-2055 aa PF00454 PI3_PI4_kinase 2158-2403 aa PF02260 FATC 2443-2474 aa

Protein ID	来源	结构域编号	结构域名称	类型	起始 aa	终止 aa	E-value	Score	说明
`XP_057769184.1`	Pfam	`PF08064`	UME	Domain	1103	1203	8.5e-19	68.0	UME (NUC010) domain
`XP_057769184.1`	Pfam	`PF25030`	M-HEAT_ATR	Repeat	1486	1734	2.9e-32	112.6	Serine/threonine-protein kinase ATR, M-HEAT region
`XP_057769184.1`	Pfam	`PF02259`	FAT	Repeat	1800	2178	1.9e-57	195.8	FAT domain
`XP_057769184.1`	Pfam	`PF23593`	HEAT_ATR	Repeat	2204	2302	6.7e-31	106.8	Serine/threonine-protein kinase ATR-like, HEAT repeats
`XP_057769184.1`	Pfam	`PF00454`	PI3_PI4_kinase	Family	2405	2650	2.8e-54	185.3	Phosphatidylinositol 3- and 4-kinase
`XP_057769184.1`	Pfam	`PF02260`	FATC	Family	2690	2721	5.3e-13	49.1	FATC domain
`XP_057769185.1`	Pfam	`PF08064`	UME	Domain	1103	1203	8.5e-19	68.0	UME (NUC010) domain
`XP_057769185.1`	Pfam	`PF25030`	M-HEAT_ATR	Repeat	1486	1734	2.9e-32	112.6	Serine/threonine-protein kinase ATR, M-HEAT region
`XP_057769185.1`	Pfam	`PF02259`	FAT	Repeat	1800	2178	1.9e-57	195.8	FAT domain
`XP_057769185.1`	Pfam	`PF23593`	HEAT_ATR	Repeat	2204	2302	6.7e-31	106.8	Serine/threonine-protein kinase ATR-like, HEAT repeats
`XP_057769185.1`	Pfam	`PF00454`	PI3_PI4_kinase	Family	2405	2650	2.8e-54	185.3	Phosphatidylinositol 3- and 4-kinase
`XP_057769185.1`	Pfam	`PF02260`	FATC	Family	2690	2721	5.3e-13	49.1	FATC domain
`XP_057769186.1`	Pfam	`PF08064`	UME	Domain	1102	1202	8.5e-19	68.0	UME (NUC010) domain
`XP_057769186.1`	Pfam	`PF25030`	M-HEAT_ATR	Repeat	1485	1733	2.9e-32	112.6	Serine/threonine-protein kinase ATR, M-HEAT region
`XP_057769186.1`	Pfam	`PF02259`	FAT	Repeat	1799	2177	1.9e-57	195.8	FAT domain
`XP_057769186.1`	Pfam	`PF23593`	HEAT_ATR	Repeat	2203	2301	6.7e-31	106.8	Serine/threonine-protein kinase ATR-like, HEAT repeats
`XP_057769186.1`	Pfam	`PF00454`	PI3_PI4_kinase	Family	2404	2649	2.8e-54	185.3	Phosphatidylinositol 3- and 4-kinase
`XP_057769186.1`	Pfam	`PF02260`	FATC	Family	2689	2720	5.3e-13	49.1	FATC domain
`XP_057769187.1`	Pfam	`PF08064`	UME	Domain	856	956	7e-19	68.3	UME (NUC010) domain
`XP_057769187.1`	Pfam	`PF25030`	M-HEAT_ATR	Repeat	1239	1487	2.4e-32	112.9	Serine/threonine-protein kinase ATR, M-HEAT region
`XP_057769187.1`	Pfam	`PF02259`	FAT	Repeat	1553	1931	1.7e-57	196.0	FAT domain
`XP_057769187.1`	Pfam	`PF23593`	HEAT_ATR	Repeat	1957	2055	5.7e-31	107.1	Serine/threonine-protein kinase ATR-like, HEAT repeats
`XP_057769187.1`	Pfam	`PF00454`	PI3_PI4_kinase	Family	2158	2403	2.7e-54	185.3	Phosphatidylinositol 3- and 4-kinase
`XP_057769187.1`	Pfam	`PF02260`	FATC	Family	2443	2474	3e-13	49.9	FATC domain

cDNA / CDS / Protein 序列

下载基因组 DNA（仅基因区域）

每个公开基因均提供参考注释对应的转录本序列；蛋白编码基因另提供 CDS 和蛋白序列。非编码 RNA 不适用 CDS 或蛋白下载。真实 accession 的版本后缀予以保留。

cDNA

4 records

下载 cDNA FASTA

XM_057913202.1
TTGAAGGTTACAAACGACTTTCCCAATACCAAAGAATAGGAGGGAAAACCATAAAAGAAAACACTCTCTCTCTCTCTCCTCGGTGCACTCTTTCGAAGAAGAGAGTTGAACTGATTTTGTAGTTTGAGCAAACGATCTAATGGCGAATTCGTCCAGCTCTCTCTAAACGGACTTCTTCTCTGCACACTCTTTCAGAACTGGAAAATCTGGAATGATTTTTTAGTTTGAGCAAACGGTTTTAATGGCGAATTTGTCGAGCC...

XM_057913201.1
TTGAAGGTTACAAACGACTTTCCCAATACCAAAGAATAGGAGGGAAAACCATAAAAGAAAACACTCTCTCTCTCTCTCCTCGGTGCACTCTTTCGAAGAAGAGAGTTGAACTGATTTTGTAGTTTGAGCAAACGATCTAATGGCGAATTCGTCCAGCTCTCTCTAAACGGACTTCTTCTCTGCACACTCTTTCAGAACTGGAAAATCTGGAATGATTTTTTAGTTTGAGCAAACGGTTTTAATGGCGAATTTGTCGAGCC...

CDS

4 records

下载 CDS FASTA

LOC130989247
ATGGCGAATTTGTCGAGCCTGGTGCACGAGCTCCGGGAGCGCATCGCGGCATCATCAGCGACTCCTAACAAGCAATACGACGACGTTTTGGTGTCTCGATTTCGCGCCGTCCTCCCCAGTCTCCTCCAAACCTACGTCGTTCCTTCATCGTCTGCTAATGAGAGAGAGGTGATTGCGGTGCTGAAGCTGCTGTCGTACACGGCGAAGAATATTCCGGTAGTTTTCTATCACGGGCAGGCGAGTGCGGTTGTTCCAGTTAT...

Protein

4 records

下载 Protein FASTA

XP_057769184.1
MANLSSLVHELRERIAASSATPNKQYDDVLVSRFRAVLPSLLQTYVVPSSSANEREVIAVLKLLSYTAKNIPVVFYHGQASAVVPVIGRILPFFAEPAFRPQHGAILEIVGTLLSLLRTGDLDAYRQFFMDAMLLTEDLLNAAQTFDGRRSGEPERLLLKSFCESFARICNHPALLGDDPDCNRPITEEGMLIDLAGRERLLAFATSTVKLLSKCLTEGTLYVEGLLDASCVLAVCKLLCFGDADLHMACFDFARLIGAG...

XP_057769185.1
MANLSSLVHELRERIAASSATPNKQYDDVLVSRFRAVLPSLLQTYVVPSSSANEREVIAVLKLLSYTAKNIPVVFYHGQASAVVPVIGRILPFFAEPAFRPQHGAILEIVGTLLSLLRTGDLDAYRQFFMDAMLLTEDLLNAAQTFDGRRSGEPERLLLKSFCESFARICNHPALLGDDPDCNRPITEEGMLIDLAGRERLLAFATSTVKLLSKCLTEGTLYVEGLLDASCVLAVCKLLCFGDADLHMACFDFARLIGAG...

上下游序列下载

upstream/downstream 最大各 10000 bp。负链基因会自动反向互补，使最终 FASTA 为转录方向 5′→3′。

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