Gene Card 基因详情

支持统一新 ID、NCBI Gene ID、GeneID、locus_tag、Transcript ID、Protein ID，以及已人工核对的文献基因名查询。页面会先解析到丹参统一基因，再整合坐标、序列、注释、亚细胞定位、EMS 突变和下载入口。

当前解析结果

`SmilChr07G002056`

染色体: Chr07 坐标: 18700051-18710246 链方向: + 类型: protein_coding

基本信息

统一新 Gene ID	`SmilChr07G002056`
名称	SmilChr07G002056
描述	crossover junction endonuclease MUS81
染色体 / SeqID	Chr07 / NC_080393.1
坐标与链方向	18700051 - 18710246 / `+`

ID 对照

NCBI Gene ID	`LOC130993137`
GeneID	`130993137`
locus_tag	`-`
NCBI Name	`LOC130993137`
原始查询	`LOC130993137`

查看完整 ID 对照表

功能注释

来源	GFF basic annotation; NCBI GO GAF; KEGG smil; Pfam-A/HMMER; Arabidopsis/Rice homolog
描述	crossover junction endonuclease MUS81
产物	crossover junction endonuclease MUS81
Arabidopsis	`AT4G30870` (MUS81) Restriction endonuclease, type II-like superfamily protein [Source:NCBI gene (formerly Entrezgene);Acc:829211] identity=52.5; qcov=1.02; evalue=3.79e-173; confidence=high
Rice	`Os01g0948100` (OsMUS81) - identity=45.5; qcov=0.974; evalue=2.69e-134; confidence=high
GO	GO:0000712 (resolution of meiotic recombination intermediates); GO:0000727 (double-strand break repair via break-induced replication); GO:0003677 (DNA binding); GO:0005634 (nucleus); GO:0006308 (DNA catabolic process); GO:0008821 (crossover junction DNA endonuclease activity); GO:0031573 (mitotic intra-S DNA damage checkpoint signaling); GO:0048257 (3'-flap endonuclease activity); GO:0048476 (Holliday junction resolvase complex)
KEGG	smil03440 (Homologous recombination - Salvia miltiorrhiza (redroot sage)); smil03460 (Fanconi anemia pathway - Salvia miltiorrhiza (redroot sage))
Pfam	PF02732 (ERCC4); PF21136 (WHD_MUS81)
InterPro	-
eggNOG	-
NR	GeneID:130993137

打开注释模块

亚细胞定位 Top 5

Rank	定位位置	中文	Score	Protein ID
1	Nucleus	细胞核	1.00000	`XP_057773895.1`
2	Nucleoplasm	核质	0.60000	`XP_057773900.1`
3	Chromosome	染色体	0.00000	`XP_057773895.1`
4	Centromere	着丝粒	0.00000	`XP_057773895.1`
5	Chromatin	染色质	0.00000	`XP_057773895.1`

进入亚细胞定位查询

EMS 诱变突变

下表显示该基因在丹参 EMS 材料中的前 12 个候选突变；完整结果可进入 EMS 突变库继续筛选或下载。

位置	REF	ALT	类型	影响	携带材料数	材料
`Chr7:18700848`	`G`	`A`	EMS_canonical_SNV	CDS_variant	4	B42,B43,B94,C37
`Chr7:18702026`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	B72
`Chr7:18702220`	`G`	`A`	EMS_canonical_SNV	CDS_variant	3	B126,B19,C19
`Chr7:18702227`	`C`	`T`	EMS_canonical_SNV	CDS_variant	3	B126,B19,C19
`Chr7:18702732`	`C`	`T`	EMS_canonical_SNV	CDS_variant	3	A10,A18,C16
`Chr7:18702995`	`G`	`A`	EMS_canonical_SNV	CDS_variant	2	B19,C19
`Chr7:18703948`	`G`	`A`	EMS_canonical_SNV	CDS_variant	2	B12,B55
`Chr7:18703999`	`C`	`T`	EMS_canonical_SNV	CDS_variant	1	B101
`Chr7:18705717`	`G`	`A`	EMS_canonical_SNV	CDS_variant	3	B126,B19,C19
`Chr7:18706366`	`C`	`T`	EMS_canonical_SNV	CDS_variant	1	D10
`Chr7:18706765`	`G`	`A`	EMS_canonical_SNV	CDS_variant	2	B104,D10
`Chr7:18709517`	`C`	`T`	EMS_canonical_SNV	CDS_variant	2	B91,C27

进入 EMS 突变库

预测功能结构域

结构域结果来自 Pfam-A HMM 数据库和 HMMER hmmscan；位置为对应蛋白序列上的氨基酸坐标。

XP_057773895.1

656 aa

328

656

WHD_MUS81

ERCC4

PF21136 WHD_MUS81 106-204 aa PF02732 ERCC4 408-538 aa

XP_057773896.1

650 aa

325

650

WHD_MUS81

ERCC4

PF21136 WHD_MUS81 106-204 aa PF02732 ERCC4 402-532 aa

XP_057773897.1

639 aa

320

639

WHD_MUS81

ERCC4

PF21136 WHD_MUS81 106-204 aa PF02732 ERCC4 408-538 aa

XP_057773898.1

628 aa

314

628

WHD_MUS81

ERCC4

PF21136 WHD_MUS81 106-204 aa PF02732 ERCC4 408-538 aa

XP_057773899.1

622 aa

311

622

WHD_MUS81

ERCC4

PF21136 WHD_MUS81 106-204 aa PF02732 ERCC4 402-532 aa

XP_057773900.1

530 aa

265

530

WHD_MUS81

ERCC4

PF21136 WHD_MUS81 26-78 aa PF02732 ERCC4 282-412 aa

Protein ID	来源	结构域编号	结构域名称	类型	起始 aa	终止 aa	E-value	Score	说明
`XP_057773895.1`	Pfam	`PF21136`	WHD_MUS81	Domain	106	204	7.9e-12	46.1	Crossover junction endonuclease MUS81-like, winged helix domain
`XP_057773895.1`	Pfam	`PF02732`	ERCC4	Domain	408	538	1.9e-24	86.9	ERCC4 domain
`XP_057773896.1`	Pfam	`PF21136`	WHD_MUS81	Domain	106	204	7.9e-12	46.1	Crossover junction endonuclease MUS81-like, winged helix domain
`XP_057773896.1`	Pfam	`PF02732`	ERCC4	Domain	402	532	1.9e-24	86.9	ERCC4 domain
`XP_057773897.1`	Pfam	`PF21136`	WHD_MUS81	Domain	106	204	7.7e-12	46.1	Crossover junction endonuclease MUS81-like, winged helix domain
`XP_057773897.1`	Pfam	`PF02732`	ERCC4	Domain	408	538	1.9e-24	86.9	ERCC4 domain
`XP_057773898.1`	Pfam	`PF21136`	WHD_MUS81	Domain	106	204	7.4e-12	46.2	Crossover junction endonuclease MUS81-like, winged helix domain
`XP_057773898.1`	Pfam	`PF02732`	ERCC4	Domain	408	538	1.9e-24	86.9	ERCC4 domain
`XP_057773899.1`	Pfam	`PF21136`	WHD_MUS81	Domain	106	204	7.3e-12	46.2	Crossover junction endonuclease MUS81-like, winged helix domain
`XP_057773899.1`	Pfam	`PF02732`	ERCC4	Domain	402	532	1.9e-24	86.9	ERCC4 domain
`XP_057773900.1`	Pfam	`PF21136`	WHD_MUS81	Domain	26	78	1.7e-07	32.2	Crossover junction endonuclease MUS81-like, winged helix domain
`XP_057773900.1`	Pfam	`PF02732`	ERCC4	Domain	282	412	1.4e-24	87.4	ERCC4 domain

cDNA / CDS / Protein 序列

下载基因组 DNA（仅基因区域）

每个公开基因均提供参考注释对应的转录本序列；蛋白编码基因另提供 CDS 和蛋白序列。非编码 RNA 不适用 CDS 或蛋白下载。真实 accession 的版本后缀予以保留。

cDNA

6 records

下载 cDNA FASTA

XM_057917912.1
ATTCCTACAACTTTCAAGTTTGAACCACTGAATCCTGGCGCCATTTTTGTACCCAAATAAATCTCCAACTGCAAACCCTAGCGAAATTGTACCCCAAAACCACCGAATTTCGCCTCAGAAACCCTAGAATTGAATCGATTAGGTAAATGGACAATGCAAGAAAGGCTGCGTGCCCGGAAAACGAAGAGGTGGCGGCGTATTTGATGAACAAGCGGCATGAATTGGCTCAGAGCTCCAAGGGAATTTCCGACAATATGGAC...

XM_057917914.1
TCAAGTTTGAACCACTGAATCCTGGCGCCATTTTTGTACCCAAATAAATCTCCAACTGCAAACCCTAGCGAAATTGTACCCCAAAACCACCGAATTTCGCCTCAGAAACCCTAGAATTGAATCGATTAGGTAAATGGACAATGCAAGAAAGGCTGCGTGCCCGGAAAACGAAGAGGTGGCGGCGTATTTGATGAACAAGCGGCATGAATTGGCTCAGAGCTCCAAGGGAATTTCCGACAATATGGACATGACGCTTTCGA...

CDS

6 records

下载 CDS FASTA

LOC130993137
ATGGACAATGCAAGAAAGGCTGCGTGCCCGGAAAACGAAGAGGTGGCGGCGTATTTGATGAACAAGCGGCATGAATTGGCTCAGAGCTCCAAGGGAATTTCCGACAATATGGACATGACGCTTTCGAAGGCTCATTCAAACATTTGTAACTACCAGAACCCAATAAGAAACCTTAAAGACTTGGCCCAGATTAAGGGTGTGGGTAAGTGGATCTTGAAGCAGATGCAAGAGTTTTTTCAGATGGATTGTGGCCCTTCTGA...

Protein

6 records

下载 Protein FASTA

XP_057773895.1
MDNARKAACPENEEVAAYLMNKRHELAQSSKGISDNMDMTLSKAHSNICNYQNPIRNLKDLAQIKGVGKWILKQMQEFFQMDCGPSEIENLTKKGNKNKGPKRYVPQKNSVAYALLISLFRGIENGNEFMHKKELIDAAETSGLSRVPIAPEKAKGKAGHFGSSPRDWYSGWNCMKTLISKGLVVKSSCPAKYMLTEEGKEVARECLLRSGMLGPNKKFDGLERCSDLAQRDKVCVDLQEDLPDLEPVMAVSVAKAATNN...

XP_057773896.1
MDNARKAACPENEEVAAYLMNKRHELAQSSKGISDNMDMTLSKAHSNICNYQNPIRNLKDLAQIKGVGKWILKQMQEFFQMDCGPSEIENLTKKGNKNKGPKRYVPQKNSVAYALLISLFRGIENGNEFMHKKELIDAAETSGLSRVPIAPEKAKGKAGHFGSSPRDWYSGWNCMKTLISKGLVVKSSCPAKYMLTEEGKEVARECLLRSGMLGPNKKFDGLERCSDLAQRDKVCVDLQEDLPDLEPVMAVSVAKAATNN...

上下游序列下载

upstream/downstream 最大各 10000 bp。负链基因会自动反向互补，使最终 FASTA 为转录方向 5′→3′。

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