Gene Card 基因详情

支持统一新 ID、NCBI Gene ID、GeneID、locus_tag、Transcript ID、Protein ID，以及已人工核对的文献基因名查询。页面会先解析到丹参统一基因，再整合坐标、序列、注释、亚细胞定位、EMS 突变和下载入口。

当前解析结果

`SmilChr01G005645`

染色体: Chr01 坐标: 72860542-72865349 链方向: + 类型: protein_coding

基本信息

统一新 Gene ID	`SmilChr01G005645`
名称	SmilChr01G005645
描述	DNA replication licensing factor MCM6
染色体 / SeqID	Chr01 / NC_080387.1
坐标与链方向	72860542 - 72865349 / `+`

ID 对照

NCBI Gene ID	`LOC131005869`
GeneID	`131005869`
locus_tag	`-`
NCBI Name	`LOC131005869`
原始查询	`LOC131005869`

查看完整 ID 对照表

功能注释

来源	GFF basic annotation; NCBI GO GAF; KEGG smil; Pfam-A/HMMER; Arabidopsis/Rice homolog
描述	DNA replication licensing factor MCM6
产物	DNA replication licensing factor MCM6
Arabidopsis	`AT5G44635` (MCM6) minichromosome maintenance (MCM2/3/5) family protein [Source:NCBI gene (formerly Entrezgene);Acc:834492] identity=74.6; qcov=1; evalue=0; confidence=high
Rice	`Os05g0235800` (OsMCM6) - identity=73.3; qcov=1.01; evalue=0; confidence=high
GO	GO:0000727 (double-strand break repair via break-induced replication); GO:0003697 (single-stranded DNA binding); GO:0005524 (ATP binding); GO:0005634 (nucleus); GO:0006268 (GO:0006268); GO:0006270 (DNA replication initiation); GO:0042555 (MCM complex); GO:1902969 (mitotic DNA replication); GO:1990518 (single-stranded 3'-5' DNA helicase activity)
KEGG	smil03030 (DNA replication - Salvia miltiorrhiza (redroot sage))
Pfam	PF00493 (MCM); PF01078 (Mg_chelatase); PF14551 (MCM_N); PF17207 (MCM_OB); PF17855 (MCM_lid); PF18263 (WHD_MCM6)
InterPro	-
eggNOG	-
NR	GeneID:131005869

打开注释模块

亚细胞定位 Top 5

Rank	定位位置	中文	Score	Protein ID
1	Nucleus	细胞核	1.00000	`XP_057788956.1`
2	Chromosome	染色体	0.80000	`XP_057788956.1`
3	Nucleoplasm	核质	0.20000	`XP_057788956.1`
4	Centromere	着丝粒	0.00000	`XP_057788956.1`
5	Chromatin	染色质	0.00000	`XP_057788956.1`

进入亚细胞定位查询

EMS 诱变突变

下表显示该基因在丹参 EMS 材料中的前 12 个候选突变；完整结果可进入 EMS 突变库继续筛选或下载。

位置	REF	ALT	类型	影响	携带材料数	材料
`Chr1:72860735`	`C`	`T`	EMS_canonical_SNV	CDS_variant	2	B111,B21
`Chr1:72860736`	`G`	`GCC`	2bp_insertion	frameshift_variant	17	A9,B135,B24,B26,B27,B36,B47,B8,B81,B91,B93,C10,C39,C50,C6,C64,C66
`Chr1:72860795`	`C`	`T`	EMS_canonical_SNV	CDS_variant	1	B24
`Chr1:72861005`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	B131
`Chr1:72861050`	`C`	`T`	EMS_canonical_SNV	CDS_variant	1	B104
`Chr1:72861903`	`C`	`T`	EMS_canonical_SNV	CDS_variant	1	B36
`Chr1:72861910`	`C`	`T`	EMS_canonical_SNV	stop_gained	42	A11,A16,A21,A7,B113,B123,B127,B128,B130,B134,B14,B23,B27,B32,B38,B4,B44,B49,B5,B56,B69,B77,B82,B85,C11,C14,C18,C22,C25,C29,C3,C31,C33,C42,C43,C44,C49,C67,C69,C7,C76,C83
`Chr1:72862200`	`AG`	`A`	1bp_deletion	frameshift_variant	1	C7
`Chr1:72862200`	`AG`	`A`	1bp_deletion	CDS_variant	1	C7
`Chr1:72862427`	`C`	`T`	EMS_canonical_SNV	CDS_variant	3	B114,B7,C60
`Chr1:72862440`	`G`	`A`	EMS_canonical_SNV	CDS_variant	3	B114,B7,C60
`Chr1:72862481`	`G`	`A`	EMS_canonical_SNV	CDS_variant	3	B114,B7,C60

进入 EMS 突变库

预测功能结构域

结构域结果来自 Pfam-A HMM 数据库和 HMMER hmmscan；位置为对应蛋白序列上的氨基酸坐标。

XP_057788956.1

824 aa

412

824

MCM_N

MCM_OB

MCM

Mg_chelatase

MCM_lid

WHD_MCM6

PF14551 MCM_N 17-113 aa PF17207 MCM_OB 119-248 aa PF00493 MCM 330-552 aa PF01078 Mg_chelatase 439-506 aa PF17855 MCM_lid 567-652 aa PF18263 WHD_MCM6 707-822 aa

Protein ID	来源	结构域编号	结构域名称	类型	起始 aa	终止 aa	E-value	Score	说明
`XP_057788956.1`	Pfam	`PF14551`	MCM_N	Domain	17	113	2.4e-16	60.6	MCM N-terminal domain
`XP_057788956.1`	Pfam	`PF17207`	MCM_OB	Domain	119	248	7.5e-41	139.5	MCM OB domain
`XP_057788956.1`	Pfam	`PF00493`	MCM	Domain	330	552	4.6e-102	340.6	MCM P-loop domain
`XP_057788956.1`	Pfam	`PF01078`	Mg_chelatase	Domain	439	506	4e-07	30.4	Magnesium chelatase, subunit ChlI
`XP_057788956.1`	Pfam	`PF17855`	MCM_lid	Domain	567	652	1.8e-24	86.8	MCM AAA-lid domain
`XP_057788956.1`	Pfam	`PF18263`	WHD_MCM6	Domain	707	822	4.8e-22	78.8	MCM6 C-terminal winged-helix domain

cDNA / CDS / Protein 序列

下载基因组 DNA（仅基因区域）

每个公开基因均提供参考注释对应的转录本序列；蛋白编码基因另提供 CDS 和蛋白序列。非编码 RNA 不适用 CDS 或蛋白下载。真实 accession 的版本后缀予以保留。

cDNA

1 records

下载 cDNA FASTA

XM_057932973.1
GACCACAGATGCCCTAACCGCATAGATACGAGCGCATCTATTCCTCTAATTCTATTCTGAGGCATACATTTTTTGAGATATAGGGTTTACTCTTCTATTCGAAAATGGAGGGCAATGGATACTGCGTGGACGAGAAGGCGGTGCATGTCGAGAAGGTGTTCTTCGACTTCCTCAAGACCTTCCGCGAGGCGGACGGCGGCGGCGGGGAGGCCTACTACGAGGCGGAGGTGGAGGCGATGAGGGCGAACGACTCCAACACC...

CDS

1 records

下载 CDS FASTA

LOC131005869
ATGGAGGGCAATGGATACTGCGTGGACGAGAAGGCGGTGCATGTCGAGAAGGTGTTCTTCGACTTCCTCAAGACCTTCCGCGAGGCGGACGGCGGCGGCGGGGAGGCCTACTACGAGGCGGAGGTGGAGGCGATGAGGGCGAACGACTCCAACACCATGTACATCGACTTCTCACATGTGATGCGCTTCAACGATGTGCTCCAGAGGGCTATCTCCGACGAATTCCTCCGATTCGAGCCTTACCTGAAGAGCGCCTGCAA...

Protein

1 records

下载 Protein FASTA

XP_057788956.1
MEGNGYCVDEKAVHVEKVFFDFLKTFREADGGGGEAYYEAEVEAMRANDSNTMYIDFSHVMRFNDVLQRAISDEFLRFEPYLKSACKRFIMELRPTFIADDNPNKDINVAFYNLPLVKKLRELATAEIGKLVAVSGVVTRTSEVRPELLQGTFKCLECGSVIKNVEQQFKYTEPIICLNATCHNRTNWALLRQESKFTDWQRVRMQESSKEIPAGSLPRSLDVILRHDIVEQARAGDTVIFTGSVVVLPDILALASPGER...

上下游序列下载

upstream/downstream 最大各 10000 bp。负链基因会自动反向互补，使最终 FASTA 为转录方向 5′→3′。

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JBrowse

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