Gene Card 基因详情

支持统一新 ID、NCBI Gene ID、GeneID、locus_tag、Transcript ID、Protein ID，以及已人工核对的文献基因名查询。页面会先解析到丹参统一基因，再整合坐标、序列、注释、亚细胞定位、EMS 突变和下载入口。

当前解析结果

`SmilChr03G003378`

染色体: Chr03 坐标: 52121745-52127255 链方向: + 类型: protein_coding

基本信息

统一新 Gene ID	`SmilChr03G003378`
名称	SmilChr03G003378
描述	BRCA1-associated RING domain protein 1
染色体 / SeqID	Chr03 / NC_080389.1
坐标与链方向	52121745 - 52127255 / `+`

ID 对照

NCBI Gene ID	`LOC131014270`
GeneID	`131014270`
locus_tag	`-`
NCBI Name	`LOC131014270`
原始查询	`LOC131014270`

查看完整 ID 对照表

功能注释

来源	GFF basic annotation; NCBI GO GAF; KEGG smil; Pfam-A/HMMER; Arabidopsis/Rice homolog
描述	BRCA1-associated RING domain protein 1
产物	BRCA1-associated RING domain protein 1
Arabidopsis	`AT1G04020` (BARD1) breast cancer associated RING 1 [Source:NCBI gene (formerly Entrezgene);Acc:839329] identity=39.7; qcov=1.1; evalue=3.94e-162; confidence=medium
Rice	`Os04g0512400` (OsRFPHC-12) - identity=37.5; qcov=1.02; evalue=7.67e-136; confidence=medium
GO	GO:0000724 (double-strand break repair via homologous recombination); GO:0004842 (ubiquitin-protein transferase activity); GO:0005886 (plasma membrane); GO:0031436 (BRCA1-BARD1 complex); GO:0035066 (GO:0035066); GO:0035067 (GO:0035067); GO:0045717 (negative regulation of fatty acid biosynthetic process); GO:0045944 (positive regulation of transcription by RNA polymerase II); GO:0070531 (BRCA1-A complex)
KEGG	smil03440 (Homologous recombination - Salvia miltiorrhiza (redroot sage))
Pfam	PF00097 (zf-C3HC4); PF00533 (BRCT); PF13445 (zf-RING_UBOX); PF13771 (zf-HC5HC2H)
InterPro	-
eggNOG	-
NR	GeneID:131014270

打开注释模块

亚细胞定位 Top 5

Rank	定位位置	中文	Score	Protein ID
1	Nucleus	细胞核	1.00000	`XP_057798173.1`
2	Chromosome	染色体	0.00000	`XP_057798173.1`
3	Centromere	着丝粒	0.00000	`XP_057798173.1`
4	Chromatin	染色质	0.00000	`XP_057798173.1`
5	Telomere	端粒	0.00000	`XP_057798173.1`

进入亚细胞定位查询

EMS 诱变突变

下表显示该基因在丹参 EMS 材料中的前 12 个候选突变；完整结果可进入 EMS 突变库继续筛选或下载。

位置	REF	ALT	类型	影响	携带材料数	材料
`Chr3:52122201`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	C14
`Chr3:52122222`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	B16
`Chr3:52125235`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	D5
`Chr3:52125477`	`G`	`A`	EMS_canonical_SNV	CDS_variant	3	B102,C77,C81
`Chr3:52125955`	`C`	`T`	EMS_canonical_SNV	CDS_variant	3	A23,B55,B84
`Chr3:52125961`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	C47
`Chr3:52126458`	`C`	`T`	EMS_canonical_SNV	CDS_variant	3	B102,C77,C81
`Chr3:52126528`	`G`	`A`	EMS_canonical_SNV	CDS_variant	3	B102,C77,C81
`Chr3:52126537`	`C`	`T`	EMS_canonical_SNV	CDS_variant	3	B102,C77,C81
`Chr3:52126813`	`C`	`T`	EMS_canonical_SNV	CDS_variant	3	B114,C10,C13
`Chr3:52127012`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	D3

进入 EMS 突变库

预测功能结构域

结构域结果来自 Pfam-A HMM 数据库和 HMMER hmmscan；位置为对应蛋白序列上的氨基酸坐标。

XP_057798173.1

659 aa

330

659

zf-RING_UBOX

zf-C3HC4

zf-HC5HC2H

BRCT

PF13445 zf-RING_UBOX 27-58 aa PF00097 zf-C3HC4 27-60 aa PF13771 zf-HC5HC2H 315-393 aa PF00533 BRCT 441-511 aa

Protein ID	来源	结构域编号	结构域名称	类型	起始 aa	终止 aa	E-value	Score	说明
`XP_057798173.1`	Pfam	`PF13445`	zf-RING_UBOX	Domain	27	58	1.3e-05	25.8	RING-type zinc-finger
`XP_057798173.1`	Pfam	`PF00097`	zf-C3HC4	Domain	27	60	0.00027	21.4	Zinc finger, C3HC4 type (RING finger)
`XP_057798173.1`	Pfam	`PF13771`	zf-HC5HC2H	Domain	315	393	8.1e-10	39.5	PHD-like zinc-binding domain
`XP_057798173.1`	Pfam	`PF00533`	BRCT	Domain	441	511	8.9e-14	52.2	BRCA1 C Terminus (BRCT) domain

cDNA / CDS / Protein 序列

下载基因组 DNA（仅基因区域）

每个公开基因均提供参考注释对应的转录本序列；蛋白编码基因另提供 CDS 和蛋白序列。非编码 RNA 不适用 CDS 或蛋白下载。真实 accession 的版本后缀予以保留。

cDNA

1 records

下载 cDNA FASTA

XM_057942190.1
GGTACCTTTTCAACTACCAGTGGAAAAAACCAAATCAACAGTTTCAGTAATAGCGGGGGGAATTCAAAATTTCGAAAGCCAAACCGCCAAGAAATTGCTCTTCCCGCTAAGTCTTGAATGCTCACCACCACCGCGGCACCGCCCATAAAGCCAAACTAATCGAGAAATTTCCATTTCATCCCCGCTTCTGAGCCCTAAAGTTAAAAAAAAGAAAGGAAGATTGCAATGTCGGAAATTCAGAACGTCGCGAGGTCGCTGAA...

CDS

1 records

下载 CDS FASTA

LOC131014270
ATGTCGGAAATTCAGAACGTCGCGAGGTCGCTGAATCCGTGTATTTTTCATCTCCAGAAGCTTCGGTTCGAGCTCAACTGCGCTTTATGTTTGAAAATGCTGAACAAGCCGATGTTGCTTCCGTGCAATCACGTTTTCTGCAATTCCTGTGTTGAATTTAGCATTCGTTGCCCTGCATGCCAGCAACGCTTTACCAATCAAGAAATCAGACCTGCCTTTCACATGGAGAACATTGTTGCTATTTACAAAAATCTGGATGC...

Protein

1 records

下载 Protein FASTA

XP_057798173.1
MSEIQNVARSLNPCIFHLQKLRFELNCALCLKMLNKPMLLPCNHVFCNSCVEFSIRCPACQQRFTNQEIRPAFHMENIVAIYKNLDATFNSAILPLISADSGTPVSSSTLTGQVTKNVGGTAPKMNDNCPDPSPRGIESAKCSASEELDVNHAPEVWPGSSPSSVDTKHANQHSSPGCRNEGPCKIRVKSSTGDQLGIVAGGVDTRGTYHTREPKRQKKLIYGPSGAVLQSHAYSEKIVSHLNPAVSKLEDCKSMEDASI...

上下游序列下载

upstream/downstream 最大各 10000 bp。负链基因会自动反向互补，使最终 FASTA 为转录方向 5′→3′。

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JBrowse

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