Gene Card 基因详情

支持统一新 ID、NCBI Gene ID、GeneID、locus_tag、Transcript ID、Protein ID，以及已人工核对的文献基因名查询。页面会先解析到丹参统一基因，再整合坐标、序列、注释、亚细胞定位、EMS 突变和下载入口。

当前解析结果

`SmilChr04G002984`

染色体: Chr04 坐标: 46256742-46262427 链方向: - 类型: protein_coding

基本信息

统一新 Gene ID	`SmilChr04G002984`
名称	SmilChr04G002984
描述	serine/threonine-protein kinase/endoribonuclease IRE1a-like
染色体 / SeqID	Chr04 / NC_080390.1
坐标与链方向	46256742 - 46262427 / `-`

ID 对照

NCBI Gene ID	`LOC131023786`
GeneID	`131023786`
locus_tag	`-`
NCBI Name	`LOC131023786`
原始查询	`LOC131023786`

查看完整 ID 对照表

功能注释

来源	GFF basic annotation; NCBI GO GAF; KEGG smil; Pfam-A/HMMER; Arabidopsis/Rice homolog
描述	serine/threonine-protein kinase/endoribonuclease IRE1a-like
产物	serine/threonine-protein kinase/endoribonuclease IRE1a-like
Arabidopsis	`AT2G17520` (IRE1A) Endoribonuclease/protein kinase IRE1-like protein [Source:NCBI gene (formerly Entrezgene);Acc:816258] identity=46; qcov=0.96; evalue=0; confidence=high
Rice	`Os07g0471000` (IRE1) - identity=41.5; qcov=0.998; evalue=1.62e-175; confidence=medium
GO	GO:0004521 (RNA endonuclease activity); GO:0004674 (protein serine/threonine kinase activity); GO:0005524 (ATP binding); GO:0006397 (mRNA processing); GO:0006468 (protein phosphorylation); GO:0036498 (IRE1-mediated unfolded protein response); GO:0051082 (GO:0051082); GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress); GO:1990604 (IRE1-TRAF2-ASK1 complex)
KEGG	smil04141 (Protein processing in endoplasmic reticulum - Salvia miltiorrhiza (redroot sage))
Pfam	PF00069 (Pkinase); PF06479 (Ribonuc_2-5A); PF07714 (PK_Tyr_Ser-Thr)
InterPro	-
eggNOG	-
NR	GeneID:131023786

打开注释模块

亚细胞定位 Top 5

Rank	定位位置	中文	Score	Protein ID
1	Endoplasmic reticulum	内质网	1.00000	`XP_057809358.1`
2	Endoplasmic reticulum membrane	内质网膜	0.80000	`XP_057809358.1`
3	Golgi apparatus	高尔基体	0.40000	`XP_057809358.1`
4	Nucleus	细胞核	0.00000	`XP_057809359.1`
5	Chromosome	染色体	0.00000	`XP_057809359.1`

进入亚细胞定位查询

EMS 诱变突变

下表显示该基因在丹参 EMS 材料中的前 12 个候选突变；完整结果可进入 EMS 突变库继续筛选或下载。

位置	REF	ALT	类型	影响	携带材料数	材料
`Chr4:46256869`	`G`	`GCA`	2bp_insertion	frameshift_variant	17	A15,A3,B137,B26,B27,B47,B51,B6,B63,B8,B89,C1,C21,C3,C34,C67,C69
`Chr4:46256874`	`A`	`AAT`	2bp_insertion	frameshift_variant	17	A15,A3,B137,B26,B27,B47,B51,B6,B63,B8,B89,C1,C21,C3,C34,C67,C69
`Chr4:46256959`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	D2
`Chr4:46257102`	`G`	`A`	EMS_canonical_SNV	stop_gained	2	C30,D9
`Chr4:46257102`	`G`	`A`	EMS_canonical_SNV	CDS_variant	2	C30,D9
`Chr4:46257113`	`G`	`A`	EMS_canonical_SNV	CDS_variant	5	B104,B105,B128,B17,C58
`Chr4:46257122`	`C`	`T`	EMS_canonical_SNV	CDS_variant	4	B27,B40,C52,C72
`Chr4:46257186`	`G`	`A`	EMS_canonical_SNV	stop_gained	4	C27,C30,C35,C47
`Chr4:46257186`	`G`	`A`	EMS_canonical_SNV	CDS_variant	4	C27,C30,C35,C47
`Chr4:46257258`	`G`	`A`	EMS_canonical_SNV	CDS_variant	2	B110,C1
`Chr4:46257365`	`CA`	`C`	1bp_deletion	frameshift_variant	28	A1,B110,B111,B113,B131,B17,B18,B23,B27,B28,B4,B41,B48,B60,B63,B68,B95,C29,C30,C54,C56,C57,C61,C64,C66,C70,C82,D11
`Chr4:46257373`	`AG`	`A`	1bp_deletion	frameshift_variant	4	B27,B40,C52,C72

进入 EMS 突变库

预测功能结构域

结构域结果来自 Pfam-A HMM 数据库和 HMMER hmmscan；位置为对应蛋白序列上的氨基酸坐标。

XP_057809358.1

915 aa

458

915

PK_Tyr_Ser-Thr

Pkinase

Ribonuc_2-5A

PF07714 PK_Tyr_Ser-Thr 491-773 aa PF00069 Pkinase 492-778 aa PF06479 Ribonuc_2-5A 784-910 aa

XP_057809359.1

806 aa

403

806

PK_Tyr_Ser-Thr

Pkinase

Ribonuc_2-5A

PF07714 PK_Tyr_Ser-Thr 382-664 aa PF00069 Pkinase 383-669 aa PF06479 Ribonuc_2-5A 675-801 aa

Protein ID	来源	结构域编号	结构域名称	类型	起始 aa	终止 aa	E-value	Score	说明
`XP_057809358.1`	Pfam	`PF07714`	PK_Tyr_Ser-Thr	Domain	491	773	2e-23	83.7	Protein tyrosine and serine/threonine kinase
`XP_057809358.1`	Pfam	`PF00069`	Pkinase	Domain	492	778	2.2e-36	126.3	Protein kinase domain
`XP_057809358.1`	Pfam	`PF06479`	Ribonuc_2-5A	Family	784	910	2e-45	154.7	Ribonuclease 2-5A
`XP_057809359.1`	Pfam	`PF07714`	PK_Tyr_Ser-Thr	Domain	382	664	1.6e-23	84.1	Protein tyrosine and serine/threonine kinase
`XP_057809359.1`	Pfam	`PF00069`	Pkinase	Domain	383	669	1.5e-36	126.9	Protein kinase domain
`XP_057809359.1`	Pfam	`PF06479`	Ribonuc_2-5A	Family	675	801	1.7e-45	155.0	Ribonuclease 2-5A

cDNA / CDS / Protein 序列

下载基因组 DNA（仅基因区域）

每个公开基因均提供参考注释对应的转录本序列；蛋白编码基因另提供 CDS 和蛋白序列。非编码 RNA 不适用 CDS 或蛋白下载。真实 accession 的版本后缀予以保留。

cDNA

2 records

下载 cDNA FASTA

XM_057953375.1
GAACTCAACAACAGTTAGGGCAAAAATATATTTTATTTAATATTTAATTTATTTATATAAATATGTCGTTTAAATTGGTGGAGGACAAAGTAGCAAGCAAGTAGTATAAAAAGTCATAAGTTTGACTTGGGAGACTAACTCAGAAGAAAAGCAAATTGGCGTCGGGCATGAGGCATTTGGCGTCTCAACGAGGAAGAAGCTACCAAAAACCACCATCTTTGATCTTCTCCAATTCACTCTTCGAATCTTCGTTACCCCTT...

XM_057953376.1
TAAAAAGTCATAAGTTTGACTTGGGAGACTAACTCAGAAGAAAAGCAAATTGGCGTCGGGCATGAGGCATTTGGCGTCTCAACGAGGAAGAAGCTACCAAAAACCACCATCTTTGATCTTCTCCAATTCACTCTTCGAATCTTCGTTACCCCTTCGATTTCTCATCCATTCTCTTCGTCTATGTAATCACCCTCGCCACTTTCTAGATCTATCTGTTTATTTATTTATATATTTGTGTATATTAAGTAGAATTAGGGGAC...

CDS

2 records

下载 CDS FASTA

LOC131023786
ATGATCCGTGAGGAGATGAATCGCCGGTTTTTTCTGCTTTTGTTGTGTGAGTTATTTTTGTTCGGGGCGTTGTACGACTCCGCGCTCGGTTCTCCGAACTCCCCATGGGGAGTGAATCGGTACGGCGCTGCTTTCCAAGCTGCGGGACGCCGGGTTTTGATGTCCGATGCTACCAAAGTGCCTGATACTGCATTAGTGGCTGCTTTGGATGGTACTATTTATCTATTGGATGTTGGTGCCCTGAAACCACTTTGGTCATT...

LOC131023786
ATGGGGAGTGAATCGGTACGGCGCTGCTTTCCAAGCTGCGGGACGCCGGGTTTTGATGTCCGATGCTACCAAAAACTTATGAAGAGTCTTGAAGAGTATATAAGTTCTACACCTCAAATAGCAGAGGATGGAGGAATTGTACTCGGTACCAAAAAGAGCTCTGCTTTTTTAGTTGATGCAAAGACTGGAAAAGTTATCCATGTATACAGAATGTCTGATTCTCCATCAACCACTGAGAGCAGTTTAAATGAATTTCCATA...

Protein

2 records

下载 Protein FASTA

XP_057809358.1
MIREEMNRRFFLLLLCELFLFGALYDSALGSPNSPWGVNRYGAAFQAAGRRVLMSDATKVPDTALVAALDGTIYLLDVGALKPLWSFSSGPKIYSSYQSPLSDKDNASGIESNYFIDCGDDWELYAHNSLGKLKLMKSLEEYISSTPQIAEDGGIVLGTKKSSAFLVDAKTGKVIHVYRMSDSPSTTESSLNEFPYNASVNKQYDSESNIKTDELPLYITRTDYTLTSFLPNSDKVLWNVTVAEIGAAFLCQDVEKSLTD...

XP_057809359.1
MGSESVRRCFPSCGTPGFDVRCYQKLMKSLEEYISSTPQIAEDGGIVLGTKKSSAFLVDAKTGKVIHVYRMSDSPSTTESSLNEFPYNASVNKQYDSESNIKTDELPLYITRTDYTLTSFLPNSDKVLWNVTVAEIGAAFLCQDVEKSLTDTLPDESSEPDLPYKMPLPCQSRALVFRFRNQNMFEALSLAHGPSKHHDMMLPSSTADVLPSQPNVEKVLELLPVQNNGGKFFEAHDSKDLEGIQPSHALNKNCGISNTH...

上下游序列下载

upstream/downstream 最大各 10000 bp。负链基因会自动反向互补，使最终 FASTA 为转录方向 5′→3′。

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