Gene Card 基因详情

支持统一新 ID、NCBI Gene ID、GeneID、locus_tag、Transcript ID、Protein ID，以及已人工核对的文献基因名查询。页面会先解析到丹参统一基因，再整合坐标、序列、注释、亚细胞定位、EMS 突变和下载入口。

当前解析结果

`SmilChr01G002574`

染色体: Chr01 坐标: 43821872-43826416 链方向: - 类型: protein_coding

基本信息

统一新 Gene ID	`SmilChr01G002574`
名称	SmilChr01G002574
描述	hydroxymethylglutaryl-CoA synthase
染色体 / SeqID	Chr01 / NC_080387.1
坐标与链方向	43821872 - 43826416 / `-`

ID 对照

NCBI Gene ID	`LOC131026271`
GeneID	`131026271`
locus_tag	`-`
NCBI Name	`LOC131026271`
原始查询	`SmilChr01G002574`

查看完整 ID 对照表

功能注释

来源	GFF basic annotation; NCBI GO GAF; KEGG smil; Pfam-A/HMMER; Arabidopsis/Rice homolog
描述	hydroxymethylglutaryl-CoA synthase
产物	hydroxymethylglutaryl-CoA synthase
Arabidopsis	`AT4G11820` (HMGS) hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase [Source:NCBI gene (formerly Entrezgene);Acc:826788] identity=81.2; qcov=1; evalue=0; confidence=high
Rice	`Os09g0521400` - identity=79.7; qcov=1.01; evalue=0; confidence=high
GO	GO:0004421 (hydroxymethylglutaryl-CoA synthase activity); GO:0006084 (acetyl-CoA metabolic process); GO:0010142 (farnesyl diphosphate biosynthetic process, mevalonate pathway)
KEGG	smil00280 (Valine, leucine and isoleucine degradation - Salvia miltiorrhiza (redroot sage)); smil00650 (Butanoate metabolism - Salvia miltiorrhiza (redroot sage)); smil00900 (Terpenoid backbone biosynthesis - Salvia miltiorrhiza (redroot sage)); smil01100 (Metabolic pathways - Salvia miltiorrhiza (redroot sage)); smil01110 (Biosynthesis of secondary metabolites - Salvia miltiorrhiza (redroot sage))
Pfam	PF01154 (HMG_CoA_synt_N); PF08540 (HMG_CoA_synt_C)
InterPro	-
eggNOG	-
NR	GeneID:131026271

打开注释模块

亚细胞定位 Top 5

Rank	定位位置	中文	Score	Protein ID
1	Cytoplasm	细胞质	1.00000	`XP_057812065.1`
2	Cytosol	细胞质基质	0.80000	`XP_057812065.1`
3	Nucleus	细胞核	0.00000	`XP_057812065.1`
4	Chromosome	染色体	0.00000	`XP_057812065.1`
5	Centromere	着丝粒	0.00000	`XP_057812065.1`

进入亚细胞定位查询

EMS 诱变突变

下表显示该基因在丹参 EMS 材料中的前 12 个候选突变；完整结果可进入 EMS 突变库继续筛选或下载。

位置	REF	ALT	类型	影响	携带材料数	材料
`Chr1:43822444`	`C`	`T`	EMS_canonical_SNV	CDS_variant	3	B59,C1,C17
`Chr1:43823452`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	B130
`Chr1:43823716`	`G`	`A`	EMS_canonical_SNV	CDS_variant	2	B4,C36
`Chr1:43824041`	`C`	`T`	EMS_canonical_SNV	CDS_variant	4	B51,B87,B89,C17
`Chr1:43824050`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	B75
`Chr1:43824685`	`T`	`TC`	1bp_insertion	frameshift_variant	209	A1,A11,A13,A14,A15,A16,A18,A19,A2,A23,A24,A25,A3,A4,A5,A6,A7,A8,A9,B1,B10,B102,B103,B105,B106,B107,B108,B109,B11,B111,B112,B113,B114,B115,B117,B118,B119,B12,B121,B122,B123,B125,B126,B127,B129,B13,B130,B131,B132,B133,B134,B136,B137,B138,B14,B140,B15,B19,B2,B21,B22,B23,B24,B25,B26,B27,B29,B3,B30,B31,B32,B33,B34,B35,B36,B37,B38,B39,B4,B40,B42,B43,B44,B45,B46,B47,B48,B49,B5,B50,B51,B52,B53,B54,B55,B56,B57,B59,B6,B60,B61,B62,B63,B64,B66,B67,B68,B69,B7,B70,B71,B72,B73,B74,B75,B76,B78,B79,B8,B80,B81,B82,B83,B84,B86,B88,B89,B9,B90,B91,B92,B94,B95,B98,B99,C10,C11,C13,C15,C17,C18,C2,C20,C21,C22,C23,C26,C27,C28,C29,C3,C30,C31,C33,C34,C35,C37,C38,C39,C4,C40,C44,C45,C46,C47,C5,C50,C53,C54,C56,C57,C6,C60,C61,C62,C65,C66,C67,C69,C7,C70,C71,C72,C73,C74,C75,C76,C77,C78,C79,C8,C80,C81,C82,C83,C84,C85,C86,C87,C9,D10,D11,D2,D3,D5,D6,D7,D8,D9
`Chr1:43824695`	`C`	`T`	EMS_canonical_SNV	CDS_variant	2	B122,B140
`Chr1:43824701`	`G`	`A`	EMS_canonical_SNV	stop_gained	78	A14,A15,A19,A3,A4,A5,A7,A8,B1,B100,B103,B109,B112,B113,B115,B122,B125,B127,B13,B132,B133,B136,B138,B21,B24,B29,B3,B32,B33,B38,B39,B44,B46,B47,B52,B53,B54,B55,B59,B62,B64,B68,B70,B72,B74,B75,B76,B80,B81,B82,B84,B88,B89,B9,B90,B91,B92,B98,B99,C13,C15,C18,C21,C26,C31,C38,C45,C53,C6,C61,C65,C72,C74,C8,C81,C85,D11,D6
`Chr1:43824741`	`CG`	`C`	1bp_deletion	frameshift_variant	1	D10
`Chr1:43824741`	`CG`	`C`	1bp_deletion	CDS_variant	1	D10
`Chr1:43824743`	`C`	`T`	EMS_canonical_SNV	CDS_variant	5	B91,C11,C19,C5,C69

进入 EMS 突变库

预测功能结构域

结构域结果来自 Pfam-A HMM 数据库和 HMMER hmmscan；位置为对应蛋白序列上的氨基酸坐标。

XP_057812065.1

460 aa

230

460

HMG_CoA_synt_N

HMG_CoA_synt_C

PF01154 HMG_CoA_synt_N 2-174 aa PF08540 HMG_CoA_synt_C 175-449 aa

Protein ID	来源	结构域编号	结构域名称	类型	起始 aa	终止 aa	E-value	Score	说明
`XP_057812065.1`	Pfam	`PF01154`	HMG_CoA_synt_N	Domain	2	174	6.4e-79	264.6	Hydroxymethylglutaryl-coenzyme A synthase N terminal
`XP_057812065.1`	Pfam	`PF08540`	HMG_CoA_synt_C	Domain	175	449	8.1e-114	380.7	Hydroxymethylglutaryl-coenzyme A synthase C terminal

cDNA / CDS / Protein 序列

下载基因组 DNA（仅基因区域）

每个公开基因均提供参考注释对应的转录本序列；蛋白编码基因另提供 CDS 和蛋白序列。非编码 RNA 不适用 CDS 或蛋白下载。真实 accession 的版本后缀予以保留。

cDNA

1 records

下载 cDNA FASTA

XM_057956082.1
GTTGGTGAGTGGAAATTCACGAAGTCTGCATTTGGGGGCTGTGGAAGCAAAGAAAATCGGAAAAATACTGAATTTATGCTCATTTCATCATCTCTTCTCTTCCCTATATATATACTACACACCACCACCTTCCAATTCTCACACCATTCAGCCACCCATTCTCTCTCTACCTCTCTGATTCCTGAGCTCTGAGACTACTGTGTGTGCTGTTTAACTGATCCGCTATTTCCTTCATTTCGTCAACTCAAGAAGTCGAGATG...

CDS

1 records

下载 CDS FASTA

LOC131026271
ATGGCCAAGAATGTCGGGATCCTCGCCATGGAAATCTACTTCCCTCCCACTTGCATCCAGCAGGAGGTATTGGAAGCTCACGATGGAGCAAGCAAAGGGAAGTACACAATTGGGCTTGGCCAAGATTGCATGGCATTTTGTTCGGAGGTTGAAGATGTCATTTCGATGAGCATGACAGCGGTTACTTCGCTTCTAGAGAAGTACAATGTTGATCCGAAGCAGATTGGACGTCTTGAAGTTGGAAGTGAAACCGTACTCGA...

Protein

1 records

下载 Protein FASTA

XP_057812065.1
MAKNVGILAMEIYFPPTCIQQEVLEAHDGASKGKYTIGLGQDCMAFCSEVEDVISMSMTAVTSLLEKYNVDPKQIGRLEVGSETVLDKSKSIKTFLMPIFEKCGNTDIEGVDSSNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPNAPIAFESKLRASHMAHVYDFYKPDLASEYPVVDGKLSQTCYLMALDACYKGFCQKFEKQEGKQFSILDADYFVFHSPYNKLVQKSFSR...

上下游序列下载

upstream/downstream 最大各 10000 bp。负链基因会自动反向互补，使最终 FASTA 为转录方向 5′→3′。

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