Gene Card 基因详情

支持统一新 ID、NCBI Gene ID、GeneID、locus_tag、Transcript ID、Protein ID，以及已人工核对的文献基因名查询。页面会先解析到丹参统一基因，再整合坐标、序列、注释、亚细胞定位、EMS 突变和下载入口。

当前解析结果

`SmilChr02G003261`

染色体: Chr02 坐标: 53900734-53908580 链方向: + 类型: protein_coding

基本信息

统一新 Gene ID	`SmilChr02G003261`
名称	SmilChr02G003261
描述	DNA mismatch repair protein MLH1
染色体 / SeqID	Chr02 / NC_080388.1
坐标与链方向	53900734 - 53908580 / `+`

ID 对照

NCBI Gene ID	`LOC131010240`
GeneID	`131010240`
locus_tag	`-`
NCBI Name	`LOC131010240`
原始查询	`SmilChr02G003261`

查看完整 ID 对照表

功能注释

来源	GFF basic annotation; NCBI GO GAF; KEGG smil; Pfam-A/HMMER; Arabidopsis/Rice homolog
描述	DNA mismatch repair protein MLH1
产物	DNA mismatch repair protein MLH1
Arabidopsis	`AT4G09140` (MLH1) MUTL-homologue 1 [Source:NCBI gene (formerly Entrezgene);Acc:826493] identity=72.9; qcov=0.993; evalue=0; confidence=high
Rice	`Os01g0958900` (OsMLH1) - identity=67.8; qcov=0.985; evalue=0; confidence=high
GO	GO:0005524 (ATP binding); GO:0006298 (mismatch repair); GO:0016887 (ATP hydrolysis activity); GO:0030983 (mismatched DNA binding); GO:0032389 (MutLalpha complex); GO:0140664 (ATP-dependent DNA damage sensor activity)
KEGG	smil03430 (Mismatch repair - Salvia miltiorrhiza (redroot sage)); smil03460 (Fanconi anemia pathway - Salvia miltiorrhiza (redroot sage))
Pfam	PF01119 (DNA_mis_repair); PF02518 (HATPase_c); PF13589 (HATPase_c_3); PF16413 (Mlh1_C)
InterPro	-
eggNOG	-
NR	GeneID:131010240

打开注释模块

亚细胞定位 Top 5

Rank	定位位置	中文	Score	Protein ID
1	Nucleus	细胞核	1.00000	`XP_057793658.1`
2	Chromosome	染色体	0.00000	`XP_057793658.1`
3	Centromere	着丝粒	0.00000	`XP_057793658.1`
4	Chromatin	染色质	0.00000	`XP_057793658.1`
5	Telomere	端粒	0.00000	`XP_057793658.1`

进入亚细胞定位查询

EMS 诱变突变

下表显示该基因在丹参 EMS 材料中的前 12 个候选突变；完整结果可进入 EMS 突变库继续筛选或下载。

位置	REF	ALT	类型	影响	携带材料数	材料
`Chr2:53900937`	`G`	`A`	EMS_canonical_SNV	CDS_variant	4	B3,B31,C64,C66
`Chr2:53901000`	`C`	`T`	EMS_canonical_SNV	CDS_variant	1	B111
`Chr2:53901044`	`C`	`T`	EMS_canonical_SNV	CDS_variant	1	C78
`Chr2:53901047`	`C`	`T`	EMS_canonical_SNV	CDS_variant	1	B24
`Chr2:53901121`	`C`	`T`	EMS_canonical_SNV	CDS_variant	1	C2
`Chr2:53901132`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	A21
`Chr2:53903087`	`C`	`T`	EMS_canonical_SNV	CDS_variant	2	B1,B68
`Chr2:53903220`	`C`	`T`	EMS_canonical_SNV	CDS_variant	2	B130,B54
`Chr2:53903383`	`G`	`A`	EMS_canonical_SNV	CDS_variant	2	B1,B68
`Chr2:53903394`	`C`	`T`	EMS_canonical_SNV	CDS_variant	4	B139,B4,B97,C4
`Chr2:53903832`	`C`	`T`	EMS_canonical_SNV	CDS_variant	2	D11,D3
`Chr2:53904051`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	C42

进入 EMS 突变库

预测功能结构域

结构域结果来自 Pfam-A HMM 数据库和 HMMER hmmscan；位置为对应蛋白序列上的氨基酸坐标。

XP_057793658.1

735 aa

368

735

HATPase_c

HATPase_c_3

DNA_mis_repair

Mlh1_C

PF02518 HATPase_c 47-108 aa PF13589 HATPase_c_3 50-151 aa PF01119 DNA_mis_repair 236-357 aa PF16413 Mlh1_C 452-735 aa

XP_057793659.1

725 aa

362

725

HATPase_c

HATPase_c_3

DNA_mis_repair

Mlh1_C

PF02518 HATPase_c 37-98 aa PF13589 HATPase_c_3 40-141 aa PF01119 DNA_mis_repair 226-347 aa PF16413 Mlh1_C 442-725 aa

Protein ID	来源	结构域编号	结构域名称	类型	起始 aa	终止 aa	E-value	Score	说明
`XP_057793658.1`	Pfam	`PF02518`	HATPase_c	Domain	47	108	1.9e-07	32.2	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
`XP_057793658.1`	Pfam	`PF13589`	HATPase_c_3	Domain	50	151	9.3e-15	55.6	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
`XP_057793658.1`	Pfam	`PF01119`	DNA_mis_repair	Family	236	357	1.7e-30	105.8	DNA mismatch repair protein, C-terminal domain
`XP_057793658.1`	Pfam	`PF16413`	Mlh1_C	Domain	452	735	6e-83	279.0	DNA mismatch repair protein Mlh1 C-terminus
`XP_057793659.1`	Pfam	`PF02518`	HATPase_c	Domain	37	98	1.9e-07	32.2	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
`XP_057793659.1`	Pfam	`PF13589`	HATPase_c_3	Domain	40	141	9.1e-15	55.6	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
`XP_057793659.1`	Pfam	`PF01119`	DNA_mis_repair	Family	226	347	1.6e-30	105.9	DNA mismatch repair protein, C-terminal domain
`XP_057793659.1`	Pfam	`PF16413`	Mlh1_C	Domain	442	725	5.8e-83	279.0	DNA mismatch repair protein Mlh1 C-terminus

cDNA / CDS / Protein 序列

下载基因组 DNA（仅基因区域）

每个公开基因均提供参考注释对应的转录本序列；蛋白编码基因另提供 CDS 和蛋白序列。非编码 RNA 不适用 CDS 或蛋白下载。真实 accession 的版本后缀予以保留。

cDNA

2 records

下载 cDNA FASTA

XM_057937676.1
CTAATAATTGTATATAAATAGTAGTATCATTTAATTTCAGTTTCACTGTGTAGAATTTGCCTTTATTTTAAAGAAGAAGAAGATAAAAGAGGAAAAATATTCTAAATCAAGGTGGAAGCTCAAGCCTCCGATCGAATGGATATGGAAGACTGTGTGCCTACTCCAGTTCAGAGGGAGCCGCCGATAATCCGACGATTGGACGAGGCGGTGATCAACAGAATTGCCGCCGGTGAGGTCATCCAACGGCCGGTCTCCGCCGT...

XM_057937675.1
CACTGTGTAGAATTTGCCTTTATTTTAAAGAAGAAGAAGATAAAAGAGGAAAAATATTCTAAATCAAGGTCTATTTGGCGCCAAATCCCTAATTTCACAACTATAATTTCATATATATATTTGATATTTGATTTGATTTGATTTCAAAATGGAGGTGGAAGCTCAAGCCTCCGATCGAATGGATATGGAAGACTGTGTGCCTACTCCAGTTCAGAGGGAGCCGCCGATAATCCGACGATTGGACGAGGCGGTGATCAACA...

CDS

2 records

下载 CDS FASTA

LOC131010240
ATGGAGGTGGAAGCTCAAGCCTCCGATCGAATGGATATGGAAGACTGTGTGCCTACTCCAGTTCAGAGGGAGCCGCCGATAATCCGACGATTGGACGAGGCGGTGATCAACAGAATTGCCGCCGGTGAGGTCATCCAACGGCCGGTCTCCGCCGTTAAGGAGCTCGTCGAAAACAGCATCGACGCCGACTCAACTTCCATCTCCGTGGTAGTGAAAGATGGTGGCCTCAAACTCATCCAAGTCTCCGATGACGGTCACGG...

LOC131010240
ATGGATATGGAAGACTGTGTGCCTACTCCAGTTCAGAGGGAGCCGCCGATAATCCGACGATTGGACGAGGCGGTGATCAACAGAATTGCCGCCGGTGAGGTCATCCAACGGCCGGTCTCCGCCGTTAAGGAGCTCGTCGAAAACAGCATCGACGCCGACTCAACTTCCATCTCCGTGGTAGTGAAAGATGGTGGCCTCAAACTCATCCAAGTCTCCGATGACGGTCACGGAATTCGATATGAAGATCTTCCAATTTTATG...

Protein

2 records

下载 Protein FASTA

XP_057793658.1
MEVEAQASDRMDMEDCVPTPVQREPPIIRRLDEAVINRIAAGEVIQRPVSAVKELVENSIDADSTSISVVVKDGGLKLIQVSDDGHGIRYEDLPILCERHTTSKLSKFEDLQSIRSMGFRGEALASMTYVSHVTVTTITKGQLHGYRATYKDGVMEYEPKACAAVKGTQIMIENLFYNMAARKKTLQNSADDYSKIVDLICRFAIHHTSVGFSCRKHGAARADVHSVATSSRLDAIRSVYGASVGQNLLKIEVSDNDPSS...

XP_057793659.1
MDMEDCVPTPVQREPPIIRRLDEAVINRIAAGEVIQRPVSAVKELVENSIDADSTSISVVVKDGGLKLIQVSDDGHGIRYEDLPILCERHTTSKLSKFEDLQSIRSMGFRGEALASMTYVSHVTVTTITKGQLHGYRATYKDGVMEYEPKACAAVKGTQIMIENLFYNMAARKKTLQNSADDYSKIVDLICRFAIHHTSVGFSCRKHGAARADVHSVATSSRLDAIRSVYGASVGQNLLKIEVSDNDPSSSSFEMDGFIS...

上下游序列下载

upstream/downstream 最大各 10000 bp。负链基因会自动反向互补，使最终 FASTA 为转录方向 5′→3′。

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