Gene Card 基因详情

支持统一新 ID、NCBI Gene ID、GeneID、locus_tag、Transcript ID、Protein ID，以及已人工核对的文献基因名查询。页面会先解析到丹参统一基因，再整合坐标、序列、注释、亚细胞定位、EMS 突变和下载入口。

当前解析结果

`SmilChr05G000429`

染色体: Chr05 坐标: 3221175-3226112 链方向: - 类型: protein_coding

基本信息

统一新 Gene ID	`SmilChr05G000429`
名称	SmilChr05G000429
描述	protein BREAST CANCER SUSCEPTIBILITY 1 homolog
染色体 / SeqID	Chr05 / NC_080391.1
坐标与链方向	3221175 - 3226112 / `-`

ID 对照

NCBI Gene ID	`LOC130985147`
GeneID	`130985147`
locus_tag	`-`
NCBI Name	`LOC130985147`
原始查询	`SmilChr05G000429`

查看完整 ID 对照表

功能注释

来源	GFF basic annotation; NCBI GO GAF; KEGG smil; Pfam-A/HMMER; Arabidopsis/Rice homolog
描述	protein BREAST CANCER SUSCEPTIBILITY 1 homolog
产物	protein BREAST CANCER SUSCEPTIBILITY 1 homolog
Arabidopsis	`AT4G21070` (BRCA1) breast cancer susceptibility1 [Source:NCBI gene (formerly Entrezgene);Acc:827854] identity=40.4; qcov=1.03; evalue=0; confidence=medium
Rice	`Os05g0512000` (OsBRCA1) - identity=49.9; qcov=0.42; evalue=5.74e-135; confidence=low
GO	GO:0000724 (double-strand break repair via homologous recombination); GO:0004842 (ubiquitin-protein transferase activity); GO:0005886 (plasma membrane); GO:0031436 (BRCA1-BARD1 complex); GO:0035066 (GO:0035066); GO:0035067 (GO:0035067); GO:0045717 (negative regulation of fatty acid biosynthetic process); GO:0045944 (positive regulation of transcription by RNA polymerase II); GO:0070531 (BRCA1-A complex)
KEGG	smil03440 (Homologous recombination - Salvia miltiorrhiza (redroot sage))
Pfam	PF00097 (zf-C3HC4); PF00533 (BRCT); PF13445 (zf-RING_UBOX); PF13639 (zf-RING_2); PF13771 (zf-HC5HC2H); PF13832 (zf-HC5HC2H_2); PF13920 (zf-C3HC4_3); PF13923 (zf-C3HC4_2)
InterPro	-
eggNOG	-
NR	GeneID:130985147

打开注释模块

亚细胞定位 Top 5

Rank	定位位置	中文	Score	Protein ID
1	Nucleus	细胞核	1.00000	`XP_057763935.1`
2	Chromosome	染色体	0.20000	`XP_057763935.1`
3	Centromere	着丝粒	0.00000	`XP_057763935.1`
4	Chromatin	染色质	0.00000	`XP_057763935.1`
5	Telomere	端粒	0.00000	`XP_057763935.1`

进入亚细胞定位查询

EMS 诱变突变

下表显示该基因在丹参 EMS 材料中的前 12 个候选突变；完整结果可进入 EMS 突变库继续筛选或下载。

位置	REF	ALT	类型	影响	携带材料数	材料
`Chr5:3221293`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	C59
`Chr5:3221340`	`C`	`T`	EMS_canonical_SNV	CDS_variant	2	B62,B93
`Chr5:3221410`	`G`	`A`	EMS_canonical_SNV	CDS_variant	5	B3,B99,C31,C76,C87
`Chr5:3221457`	`C`	`T`	EMS_canonical_SNV	CDS_variant	3	B107,C5,C85
`Chr5:3221475`	`C`	`T`	EMS_canonical_SNV	CDS_variant	1	A10
`Chr5:3221540`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	B40
`Chr5:3221999`	`G`	`A`	EMS_canonical_SNV	CDS_variant	1	A20
`Chr5:3222017`	`C`	`T`	EMS_canonical_SNV	CDS_variant	5	A6,B57,B71,B80,C85
`Chr5:3222035`	`C`	`T`	EMS_canonical_SNV	CDS_variant	2	B94,C16
`Chr5:3222056`	`C`	`T`	EMS_canonical_SNV	CDS_variant	1	D6
`Chr5:3222084`	`C`	`T`	EMS_canonical_SNV	CDS_variant	1	A15
`Chr5:3222261`	`G`	`A`	EMS_canonical_SNV	stop_gained	1	C29

进入 EMS 突变库

预测功能结构域

结构域结果来自 Pfam-A HMM 数据库和 HMMER hmmscan；位置为对应蛋白序列上的氨基酸坐标。

XP_057763935.1

978 aa

489

978

zf-C3HC4_3

zf-C3HC4_2

zf-RING_2

zf-RING_UBOX

zf-C3HC4

zf-HC5HC2H_2

zf-HC5HC2H

BRCT

PF13920 zf-C3HC4_3 13-58 aa PF13923 zf-C3HC4_2 15-53 aa PF13639 zf-RING_2 15-54 aa PF13445 zf-RING_UBOX 16-51 aa PF00097 zf-C3HC4 16-53 aa PF13832 zf-HC5HC2H_2 618-682 aa PF13771 zf-HC5HC2H 622-700 aa PF00533 BRCT 749-829 aa

Protein ID	来源	结构域编号	结构域名称	类型	起始 aa	终止 aa	E-value	Score	说明
`XP_057763935.1`	Pfam	`PF13920`	zf-C3HC4_3	Domain	13	58	1.1e-06	29.1	Zinc finger, C3HC4 type (RING finger)
`XP_057763935.1`	Pfam	`PF13923`	zf-C3HC4_2	Domain	15	53	6.9e-10	39.3	Zinc finger, C3HC4 type (RING finger)
`XP_057763935.1`	Pfam	`PF13639`	zf-RING_2	Domain	15	54	1.7e-08	35.3	Ring finger domain
`XP_057763935.1`	Pfam	`PF13445`	zf-RING_UBOX	Domain	16	51	8.3e-09	36.0	RING-type zinc-finger
`XP_057763935.1`	Pfam	`PF00097`	zf-C3HC4	Domain	16	53	1.6e-07	31.7	Zinc finger, C3HC4 type (RING finger)
`XP_057763935.1`	Pfam	`PF13832`	zf-HC5HC2H_2	Domain	618	682	1.6e-06	28.9	PHD-zinc-finger like domain
`XP_057763935.1`	Pfam	`PF13771`	zf-HC5HC2H	Domain	622	700	1.3e-09	38.8	PHD-like zinc-binding domain
`XP_057763935.1`	Pfam	`PF00533`	BRCT	Domain	749	829	4.8e-15	56.2	BRCA1 C Terminus (BRCT) domain

cDNA / CDS / Protein 序列

下载基因组 DNA（仅基因区域）

每个公开基因均提供参考注释对应的转录本序列；蛋白编码基因另提供 CDS 和蛋白序列。非编码 RNA 不适用 CDS 或蛋白下载。真实 accession 的版本后缀予以保留。

cDNA

1 records

下载 cDNA FASTA

XM_057907952.1
AAAACAAACACGAACTCTATTAACTTCTCAGATACTCACACACAACAGTGTTCATCACTCCCAAAGAGAAATAGGGATAGCGAGAGAATCGGAAGAGAATAATGGCGGACGCATCGCATTTGGAAAGGATGGGAAGGGAGCTCAAGTGCCCTATATGTTTGAGTCTATTTAATTCAGCTGTTTCACTCACCTGCAATCATGTATTTTGCAATTCGTGTATCGAGAAATCCATGAAAGCAGCATCGAGTTGTCCTGTTTGT...

CDS

1 records

下载 CDS FASTA

LOC130985147
ATGGCGGACGCATCGCATTTGGAAAGGATGGGAAGGGAGCTCAAGTGCCCTATATGTTTGAGTCTATTTAATTCAGCTGTTTCACTCACCTGCAATCATGTATTTTGCAATTCGTGTATCGAGAAATCCATGAAAGCAGCATCGAGTTGTCCTGTTTGTAAAGTTCCATATCGGCGAAGAGAAATTAGGCCTGCTCCTCATATGGATAACTTGGTTAGCGTTTACAAAAGCATGGAAGTAGCATCTGGAGTCAGTATTTT...

Protein

1 records

下载 Protein FASTA

XP_057763935.1
MADASHLERMGRELKCPICLSLFNSAVSLTCNHVFCNSCIEKSMKAASSCPVCKVPYRRREIRPAPHMDNLVSVYKSMEVASGVSIFVTQTEASTGPSGNKNDKTGVNVNEVQNNVQTKLEVSEFGNRKQHQRKGSKSASVFPTKKRVQVSPHTSTRTDMKQGKLKDGIAEINRNETKSSPVLQNDVPSICENGGPKLPPFFWLREQEDMEKSTQQTDDNSVMYTPPEAPCFSDIKDSDDERGTCKLSNNADFIDSEMFD...

上下游序列下载

upstream/downstream 最大各 10000 bp。负链基因会自动反向互补，使最终 FASTA 为转录方向 5′→3′。

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